Molecular modelling reveals how abundance of α4 sub-type in synaptic GABARA receptor can lead to refractoriness toward GABA and BZ-type drugs

This work suggests a mechanism for development of drug resistance in epilepsy patients, when the post-synaptic neurons express non-standard ALPHA4 proteins in the synaptic GABARA receptor. The structural details can be useful in developing drugs effective against resistant epilepsy.