Unfolding of hen egg-white lysozyme – is there a unique starting point?

Folding and unfolding of proteins is a biologically important topic as many neurological diseases involve misfolding of proteins. Here we have used the technique of X-ray crystallography to characterise the early stages of unfolding of the protein lysozyme purified from hen egg-white. The results when compared with our earlier studies reveal, for the first-time, the possibility of protein unfolding to start from a unique point. If true, this would enable engineering of proteins and drugs to prevent neurological disorders.